The significance of copy number variations in schizophrenia.
نویسنده
چکیده
منابع مشابه
Failure to confirm CNVs as of aetiological significance in twin pairs discordant for schizophrenia.
Copy number variations (CNVs) are common structural variations in the human genome that strongly affect genomic diversity and can play a role in the development of several diseases, including neurodevelopmental disorders. Recent reports indicate that monozygotic twins can show differential CNV profiles. We searched CNVs in monozygotic twins discordant for schizophrenia to identify susceptible l...
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IntroductIon Genetic variations within the human genome can take many forms, including single-nucleotide polymorphisms (SNPs), copy number variations (CNVs), and copy-neutral loss of heterozygosity (LOH). SNPs involve the change in a single nucleotide, while CNVs and LOH encompass larger segments of DNA. In this application note, we focus on methods for accurately mapping these structural varia...
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Autism is a common neuropsychiatric disorder affecting 1 in 68 children. Copy number variations (CNVs) are known to be major contributors of autism spectrum disorder (ASD). There are different whole genome or targeted techniques to identify CNVs in the patients including karyotyping, multiplex ligation-dependent probe amplification (MLPA) and array CGH. In this study, we used karyotyping and ML...
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Schizophrenia is a psychiatric disorder with onset in late adolescence and unclear etiology characterized by both positive and negative symptoms, as well as cognitive deficits. To identify copy number variations (CNVs) that increase the risk of schizophrenia, we performed a whole-genome CNV analysis on a cohort of 977 schizophrenia cases and 2,000 healthy adults of European ancestry who were ge...
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عنوان ژورنال:
- The British journal of psychiatry : the journal of mental science
دوره 205 1 شماره
صفحات -
تاریخ انتشار 2014